ISRAELI CANCER RESEARCH FIRM VAXIL GRANTED 9th PATENT FOR IMMUNOTHERAPY TREATMENT
Provides Corporate Update
Wednesday May 3rd 2018 – ISRAEL – TORONTO – VAXIL BIO LTD. (TSX VENTURE: VXL), a cancer research biotechnology company focused on innovative immunotherapy treatments, has been granted a patent from the Indian Patent Office for its ImMucinTM cancer immunotherapy. The granted Indian patent has been assigned as Patent No. 294701 entitled “Antigen Specific Multi Epitope Vaccines”.
Vaxil’s lead product, ImMucinTM, has already completed a Phase-I/II in 15 cancer patients in Israel. ImMucinTM is an immunotherapy treatment intended to train and harness cancer patients’ immune systems, particularly T-cells and antibodies, to attack cancer cells. ImMucin has also been granted Orphan Drug Designation from both the FDA and EMA for the treatment of multiple myeloma, although Vaxil hopes to test its applicability on other MUC1 cancer types as well.
“We are pleased to have been granted broad patent coverage for our lead cancer immunotherapy treatment in a variety of key jurisdictions around the globe. ImMucinTM is now protected in the United States of America, the European Union, Canada, Australia, Israel, and India” noted Vaxil CEO Mr. Isaac Maresky. “Vaxil has advanced from a single Israeli patent to the present nine patents – including three US patents on all Vaxil product candidates – most of which have been obtained in just the past couple years.”
Vaxil’s treatment exposes the signal peptide domain, essentially a specific portion of a prominent cancer marker called MUC1 which is present in approximately 90% of cancer types. Vaxil believes that its specific peptide may have potential to offer significant advantages as an immunotherapy treatment.
The granted patent includes claims covering the ImMucinTM 21-mer peptide nucleotide sequence and expression vector encoding the ImMucinTM peptide, as well as vaccines and pharmaceutical composition comprising the vaccine being the ImMucinTM peptide.
As mentioned in its most recent announcement: “Vaxil remains focused on advancing the drug manufacturing processes for its lead cancer immunotherapy product known as ImMucinTM. While manufacturing of the drug substance has begun, the Company is in discussions with relevant experts pertaining to Chemistry, Manufacturing and Controls (CMC). The Company is working on identifying an optimal CMC process for production of its drug which will in turn allow efficient production via a Current Good Manufacturing Practices (CGMP) approved facility. The goal of such an endeavor is to enhance Vaxil’s ability to more readily produce larger quantities of high quality product, which would enable the Company to embark upon additional clinical trials. CMC is an important bridge between clinical pilot batches of therapeutic drugs to more commercial-scale batches. The Company hopes to be in a position to report more on the manufacturing process and its CMC direction in the near future.” This process remains underway with relevant testing in process.
Vaxil is an Israeli immunotherapy biotech focused on its novel approach to targeting prominent cancer markers utilizing its platform algorithm known as VaxHitTM. Its lead product Immucin™ is a MUC1 signal peptide derived product, wholly owned by Vaxil and protected by a series of patents in several major territories around the globe, believed to act as a true neoantigen. Vaxil has also developed an antibody platform, SPmAbTM and a Tuberculosis vaccine called MTBuVaxTM with R&D underway in Israel.
Information about the Company’s pipeline, including published medical journal articles available for direct download, is available at www.vxlbio.com
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